Dichloromethane → HCID 131713457, compound

Participants

Reaction Steps

A mixture of 0.683 g of the syn isomer of 3-acetoxymethyl-7-[2-(2-tritylamino-4-thiazolyl)-2-(hydroxyimino)-acetamido]-ceph-3-eme-4-carboxylic acid, 10 ml of methylene chloride, 0.2 ml of pyridine and 0.2 ml of benzoyl chloride was stirred at room temperature for 10 minutes and was washed with water acidified to a pH of 1. The organic phase was dried, vacuum filtered and evaporated to dryness to obtain 0.737 g of raw product. The latter was dissolved in 5 ml of ethyl acetate and 0.1 ml of diethylamine was added thereto. After 10 minutes, the mixture was vacuum filtered to obtain 0.27 g of the syn isomer of diethylamine 3-acetoxymethyl-7-[2-(2-tritylamino-4-thiazolyl)-2-(phenylcarbonyloxyimino)-acetamido]-ceph-3-eme-4-carboxylate.

Provenance & Evidence