Potassium Hydroxide → HCID 74088765, compound

Participants

Reaction Steps

A mixture of 2.88 g of the said ester and 4.3 ml of dioxane was stirred under an inert atmosphere at room temperature until dissolution occured and then 30.6 ml of a solution of 0.5 M potassium hydroxide in ethanol were added thereto over 3 minutes at 20°-25° C. The mixture was stirred at room temperature under an inert atmosphere for 24 hours and after 2 or 3 hours a potassium salt crystallized. The mixture was vacuum filtered at room temperature and the recovered product was rinsed with 1 ml of ether and 3 times with 2 ml of methylene chloride to obtain 1.6 g of the syn isomer of potassium 2-(2-tritylamino-4-thiazolyl)-2-(2-bromoethoxyimino)-acetate.

Provenance & Evidence