Dicyclohexylcarbodiimide → HCID 73708098, compound

Participants

Reaction Steps

A mixture of 9.84 g of the product of Step B, 2.93 g of 1-hydroxy-1H-benzotriazol, 4.88 g of dicyclohexylcarbodiimide and 130 ml of anhydrous methylene chloride was stirred for 20 hours at room temperature and was vacuum filtered to remove dicyclohexylurea. The filtrate was washed with aqueous sodium bicarbonate solution, then with water, was dried and evaporated to dryness under reduced pressure. The residue was taken up in ethyl acetate and after cooling the mixture at 0° C. for 30 minutes, the mixture was vacuum filtered to obtain 7.31 g of 1-hydroxy-1H-benzotriazole 2-(2-tritylamino-4-thiazolyl)-2-(2-azidoethoxyimino)-acetate. Another 1.5 g of the product were recovered by evaporation of the filtrate.

Provenance & Evidence