Hydrochloric Acid → HCID 131713466, compound

Participants

Reaction Steps

A mixture of 2.54 g of 7-amino-cephalosporanic acid, 25 ml of anhydrous methylene chloride and 2.6 ml of triethylamine was stirred at room temperature for 15 minutes and then 6.02 g of 1-hydroxy-1H-benzotriazole 2-(2-tritylamino-4-thiazolyl)-2-(2-azidoethoxyimino)-acetate were added thereto. The mixture was stirred at room temperature for 45 hours and 25 ml of water and 5 ml of N hydrochloric acid were added thereto. The decanted organic phase was washed with water, dried and evaporated to dryness under reduced pressure. The residue was taken up in 30 ml of ethyl acetate and 2.4 ml of diethylamino were added to the solution. The mixture was cooled at 0° C. and was vacuum filtered to obtain 5.9 g of the syn isomer of diethylamine 3-acetoxymethyl-7-[2-(2-tritylamino-4-thiazolyl)-2-(2-azidoethoxyimino)-acetamido]-ceph-3-eme-4-carboxylate.

Provenance & Evidence