Ethanol → HCID 131713469, compound

HRID 1904141Notes

Reaction equation

HRID 1904141 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:33])[C:19]([C:27]3[N:28]=[C:29]([NH2:32])[S:30][CH:31]=3)=[N:20][O:21][CH2:22][CH2:23][N:24]=[N+:25]=[N-:26])[C:15](=[O:34])[N:10]2[C:11]=1[C:12]([OH:14])=[O:13])(=[O:3])[CH3:2].C([O-])(=O)C.[Na+:39].C(O)C>CO>[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:33])[C:19]([C:27]3[N:28]=[C:29]([NH2:32])[S:30][CH:31]=3)=[N:20][O:21][CH2:22][CH2:23][N:24]=[N+:25]=[N-:26])[C:15](=[O:34])[N:10]2[C:11]=1[C:12]([O-:14])=[O:13])(=[O:3])[CH3:2].[Na+:39]

Participants

5

Reactant 3

HCID 702EthanolHCID 517045Sodium AcetateHCID 131713468HCID 131713468, compound

Product 1

HCID 131713469HCID 131713469, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.385 g of the acid of Example 32 was added to 1 ml of a molar solution of sodium acetate in methanol to obtain a lipid solution to which 5 ml of ethanol were slowly added. The mixture was vacuum filtered and the recovered product was rinsed with ethanol and then ether to obtain 0.215 g of the syn isomer of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-(2-azidoethoxyimino)-acetamido]-ceph-3-eme-4-carboxylate.

Workup

  1. additionwere slowly added
  2. filtrationfiltered
  3. washthe recovered product was rinsed with ethanol

Sources & evidence

ORD record
ord-6c2999cb1eca4ee390e86edde27772f1
Source dataset
uspto-grants-1984_03
Patent number
US04439433

Reaction notes

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