Sodium Acetate → HCID 131713472, compound

HRID 1904143Notes

Reaction equation

HRID 1904143 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:31])[C:19]([C:25]3[N:26]=[C:27]([NH2:30])[S:28][CH:29]=3)=[N:20][O:21][CH2:22][CH2:23][NH2:24])[C:15](=[O:32])[N:10]2[C:11]=1[C:12]([OH:14])=[O:13])(=[O:3])[CH3:2].C([O-])(=O)C.[Na+:37]>CO.C(O)C>[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:31])[C:19]([C:25]3[N:26]=[C:27]([NH2:30])[S:28][CH:29]=3)=[N:20][O:21][CH2:22][CH2:23][NH2:24])[C:15](=[O:32])[N:10]2[C:11]=1[C:12]([O-:14])=[O:13])(=[O:3])[CH3:2].[Na+:37]

Participants

5

Reactant 2

HCID 517045Sodium AcetateHCID 131713470HCID 131713470, compound

Product 1

HCID 131713472HCID 131713472, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

The product of Example 34 was dissolved in 0.2 ml of a molar solution of sodium acetate in methanol and 0.4 ml of ethanol was slowly added thereto. The mixture was vacuum filtered and the filtrate was evaporated to dryness under reduced pressure. The residue was taken up in ethanol and after efflorescence, the mixture was vacuum filtered to obtain 0.047 g of the syn isomer of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-(2-aminoethoxyimino)-acetamido]-ceph-3-eme-4-carboxylate.

Workup

  1. additionwas slowly added
  2. filtrationfiltered
  3. customthe filtrate was evaporated to dryness under reduced pressure
  4. filtrationfiltered

Sources & evidence

ORD record
ord-1db8fa31752a4bc1ad3c3f3235605108
Source dataset
uspto-grants-1984_03
Patent number
US04439433

Reaction notes

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