Hydrochloric Acid → HCID 131713473, compound

Participants

Reaction Steps

A mixture of 0.652 g of 3-[(1-methyl-1H-tetrazol-5-yl)-thiomethyl]-7-amino-ceph-3-eme-4-carboxylic acid, 6.5 ml of methylene chloride and 0.56 ml of triethylamine was stirred at room temperature for 15 minutes and then 1.29 g of 1-hydroxy-1H-benzotriazole 2-(2-azidoethoxyimino)-2-(2-tritylamino-4-thiazolyl)-acetate were added thereto. The mixture was stirred at room temperature for 20 hours and then 10 ml of water and 3 ml of 2 N hydrochloric acid were added thereto. The decanted organic phase was washed with water, dried and evaporated to dryness under reduced pressure. The residue was taken up in 5 ml of ethyl acetate and 10 ml of ether were added thereto. The mixture was stirred for 30 minutes at room temperature and was vacuum filtered to obtain 1.416 g of raw syn isomer of 3-[(1-methyl-1H-tetrazol-5-yl)-thiomethyl]-7-[2-(2-tritylamino-4-thiazolyl)-2-(2-azidoethoxyimino)-acetamido]-ceph-3-eme-4-carboxylic acid.

Provenance & Evidence