Formic Acid → HCID 131713474, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.336 g of the product of Step A and 7 ml of formic acid were stirred at 50° C. for 15 minutes and was vacuum filtered to remove triphenylcarbinol. The filtrate was evaporated to dryness and the residue was taken up in water. After efflorescence, the mixture was vacuum filtered to obtain 0.77 g of raw product which was dissolved in minimum of aqueous 10% sodium bicarbonate solution. 0.77 g of activated carbon were added thereto and the mixture was vacuum filtered. Formic acid was added to the filtrate to adjust the pH to 2 and the mixture was vacuum filtered to obtain 0.171 g of syn isomer of 3-[(1-methyl-1H-tetrazol-5-yl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-(2-azidoethoxyimino)-acetamido]-ceph-3-eme-4-carboxylic acid.

Provenance & Evidence