化工社化工社 化学情報印刷レポート · 研究参考用
1-Pentanol → 3-Methoxy-6-(2',6'-dimethylanilino)toluene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Pentanol | HCID 6276 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Bromo-m-xylene | HCID 68471 | — |
| 反応物 | N-(4-Methoxy-2-methylphenyl)-acetamide | HCID 95082 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 生成物 | 3-Methoxy-6-(2',6'-dimethylanilino)toluene | HCID 10857633 | 28.6% |
反応手順
A mixture of 14.3 g of 3-methoxy-6-acetylaminotoluene, 17.8 g of 2-bromo-m-xylene, 6.6 g of potassium carbonate, and 0.3 g of copper (I) iodide was stirred for 42 hours at 160°-210° C. After the reaction mixture was cooled, 22.9 g of potassium hydroxide and 66 ml of n-amyl alcohol were added to the mixture, which was then refluxed for 3.5 hours. Then the reaction mixture was cooled and washed with hot water. The n-amyl alcohol was removed by distillation, and the remaining reaction mixture was distilled under reduced pressure to obtain 5.5 g (28 percent of theoretical yield) of 3-methoxy-6-(2',6'-dimethylanilino)toluene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04837210 |
| 出典データセット | uspto-grants-1989_06 |
| ORD ID | ord-0998187707c44267a0194c17ddd3df7a |
| 出典メモ | uspto-grants-1989_06 |