HCID 14478725, compound → HCID 14478727, compound

HRID 1904205Notes

Reaction equation

HRID 1904205 reaction equation
[N:1]([CH2:4][C@H:5]([OH:24])[C@H:6]([OH:23])[C@@H:7]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[N+]=[N-]>[Pd].CO>[NH2:1][CH2:4][C@H:5]([OH:24])[C@H:6]([OH:23])[C@@H:7]([NH:15][C:16]([O:18][C:19]([CH3:20])([CH3:22])[CH3:21])=[O:17])[CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 14478725HCID 14478725, compound

Product 1

HCID 14478727HCID 14478727, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The resultant compound from Example 8 (107 mg, 0.313 mmol) and 10% palladium on carbon (110 mg) in methanol (10 mL) were stirred under a hydrogen atmosphere for 18 hours. The mixture was filtered and evaporated to afford 94.6 mg (96%) of the desired compound. Mass spectrum: (M+H)+ =317.

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-dbd4301565e44588b2b5818b90e8033d
Source dataset
uspto-grants-1989_06
Patent number
US04837204

Reaction notes

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