HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-isothiocyanatobenzoate → N-(2-(2,5-Dimethyl-1-pyrrolyl)ethyl)-N'-(4-ethoxycarbonylphenyl)-thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-isothiocyanatobenzoate | HCID 71003 | — |
| Reactant | 2-(2,5-Dimethyl-1H-pyrrol-1-yl)ethan-1-amine | HCID 13770050 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | N-(2-(2,5-Dimethyl-1-pyrrolyl)ethyl)-N'-(4-ethoxycarbonylphenyl)-thiourea | HCID 13770053 | — |
Reaction Steps
8.3 g (0.04 mol) of 4-ethoxy carbonylphenyl isothiocyanate in 20 ml of ethylene glycol dimethyl ether are added dropwise at room temperature to 5.5 g (0.04 mol) of 1-(2-aminoethyl)-2,5-dimethylpyrrole in 20 ml of ethylene glycol dimethyl ether. The precipitated product is filtered off with suction and recrystallized from methanol. Yield: 5.1 g (37% of theory) Melting point: 155°-156° C. Elemental analysis: C18H23N3O2S (345.47) calculated: C 62.6 H 6.7 N 12.2 0. 9.3 S 9.3 found: C 62.0 H 6.7 N 11.6 0 10.0 S 9.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04837225 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-c2218106b72f405db961502ee182a182 |
| Source note | uspto-grants-1989_06 |