反应详情

2.8 g (0.008 mol) of N-(2-(2,5-dimethyl-1-pyrolyl)ethyl)-N'-(4-ethoxycarbonylphenyl)thiourea, prepared as in Example 9, are stirred with 10 ml of 1 N sodium hydroxide solution at room temperature for 5 h and under reflux for 15 min. After cooling, the mixture is filtered, and the filtrate is acidified and the product is filtered off with suction. yield: 1.9 g (75% of theory), Melting point: 174°-175° C. Elemental analysis: C16H19N3O2S (317.41) calculated C 60.5 H 6.0 N 13.2 0 10.1 S 10.1 found: C 59.9 H 5.9 N 13.6 0 10.7 S 9.9

1. temperatureunder reflux for 15 min
2. temperatureAfter cooling
3. filtrationthe mixture is filtered
4. filtrationthe product is filtered off with suction