Water → HCID 86743100, compound

Participants

Reaction Steps

3.5 g (0.02 mol) of 5-oxoperhydro-1,4-thiazepine-3-carboxylic acid and 2.8 g (0.02 mol) of 1-(2-aminoethyl)-2,5-dimethylpyrrole are dissolved in 10 ml of dimethylformamide. After addition of 4.2 g (0.02 mol) of dicyclohexylcarbodiimide, dissolved in 10 ml of methylene chloride, to the mixture at 0° C., it is stirred at room temperature for 24 h, then water is added and the mixture is filtered with suction. The filtrate is extracted with methylene chloride, and the extract is chromatographed over a silica gel column using ethyl acetate as the mobile phase. Yield: 1.2 g (20% of theory), Melting point: 181°-183° C. Elemental analysis: C14H21N3O2S (295.41) calculated: C 56.9 H 7.2 N 14.2 0 10.8 S 10.9 found: C 57.4 H 6.9 N 13.8 0 11.2 S 10.8

Provenance & Evidence