反应详情

To 75 ml of ethanol were added 17.0 g (0.085 mol) of 2-t-butyl-5-chloro-4-methyl-3(2H)-pyridazinone and 8.5 g (0.106 mol) of 70% sodium hydrosulfide and the mixture was stirred under reflax for 4 hours. After cooling, the mixture was poured into 300 ml of ice water and extracted with 200 ml of ethyl ether. The ether layer was washed with 100 ml of water, dried over anhydrous sodium sulfate and then freed of solvent by distillation to obtain 16.3 g of a crude product.

1. temperatureAfter cooling
2. extractionextracted with 200 ml of ethyl ether
3. washThe ether layer was washed with 100 ml of water
4. dry with materialdried over anhydrous sodium sulfate
5. distillationfreed of solvent by distillation