HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-t-butyl-4-chloro-5-[4-(2-propoxyethoxy)-benzyloxy]-3(2H)-pyridazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(2-Propoxyethoxy)-benzyl bromide | HCID 14671803 | — |
| Reactant | 2-tert-Butyl-4-chloro-5-hydroxypyridazin-3(2H)-one | HCID 54686946 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-t-butyl-4-chloro-5-[4-(2-propoxyethoxy)-benzyloxy]-3(2H)-pyridazinone | HCID 14671804 | 35.9% |
Reaction Steps
In 30 ml of N,N-dimethylformamide were dissolved 2.0 g of 2-t-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinone and 3.0 g of 4-(2-propoxyethoxy)-benzyl bromide, and then 2.0 g of anhydrous potassium carbonate was added thereto. The mixture was heated under stirring on an oil bath at 80° to 90° C. for 3 hours. Then, procedures similar to those in Preparation Example 2 were carried out to obtain 1.4 g of the aimed product as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04837217 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-963b6b19bbd74725996dd736ebbe4847 |
| Source note | uspto-grants-1989_06 |