4-(1-Methyl-2-propoxyethoxy)-benzyl bromide → 2-t-butyl-4-chloro-5-[4-(1-methyl-2-propoxyethoxy)-benzyloxy]-3(2H)-pyridazinone

HRID 1904241Notes

Reaction equation

HRID 1904241 reaction equation
[C:1]([N:5]1[C:10](=[O:11])[C:9]([Cl:12])=[C:8]([OH:13])[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[CH3:14][CH:15]([O:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26]Br)=[CH:24][CH:23]=1)[CH2:16][O:17][CH2:18][CH2:19][CH3:20]>>[C:1]([N:5]1[C:10](=[O:11])[C:9]([Cl:12])=[C:8]([O:13][CH2:26][C:25]2[CH:24]=[CH:23][C:22]([O:21][CH:15]([CH3:14])[CH2:16][O:17][CH2:18][CH2:19][CH3:20])=[CH:29][CH:28]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 200386184-(1-Methyl-2-propoxyethoxy)-benzyl bromideHCID 546869462-tert-Butyl-4-chloro-5-hydroxypyridazin-3(2H)-one

Product 1

HCID 146718082-t-butyl-4-chloro-5-[4-(1-methyl-2-propoxyethoxy)-benzyloxy]-3(2H)-pyridazinoneYield 35.4%

Procedure

Procedures similar to those in Preparation Example 8 were carried out by using 2.0 g of 2-t-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinone and 3.1 g of 4-(1-methyl-2-propoxyethoxy)-benzyl bromide to obtain 1.43 g of the aimed compound as an oil.

Workup

  1. customProcedures similar to those in Preparation Example 8

Sources & evidence

ORD record
ord-911014d3371b4c4ead2cda1c51de4c19
Source dataset
uspto-grants-1989_06
Patent number
US04837217

Reaction notes

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