HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-t-butyl-4-chloro-5-[4-(1-methyl-2-isopropoxyethoxy)-benzyloxy]-3(2H)-pyridazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 14671811 | HCID 14671811 | — |
| Reactant | 2-tert-Butyl-4-chloro-5-hydroxypyridazin-3(2H)-one | HCID 54686946 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-t-butyl-4-chloro-5-[4-(1-methyl-2-isopropoxyethoxy)-benzyloxy]-3(2H)-pyridazinone | HCID 14671812 | 59.5% |
Reaction Steps
In 15 ml of N,N-dimethylformamide were dissolved 1.0 g of 2-t-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinone and 1.6 g of 4-(1-methyl-2-isopropoxyethoxy)-benzyl bromide, and thereto was added 1.0 g of anhydrous potassium carbonate. The mixture was heated under stirring on an oil bath at 100° to 120° C. for 2 hours. Then, procedures similar to those in Preparation Example 2 were conducted to give 1.2 g of the aimed compound, m.p. 60.0°~62.0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04837217 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-84a401e68cbd492489328394131daea5 |
| Source note | uspto-grants-1989_06 |