Water → HCID 14671832, compound

HRID 1904257Notes

Reaction equation

HRID 1904257 reaction equation
[C:1]([N:5]1[C:10](=[O:11])[C:9]([Cl:12])=[C:8](Cl)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[SH:14][CH2:15][C:16]1[CH:17]=[CH:18][C:19]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])=[N:20][CH:21]=1.C(=O)([O-])[O-].[Na+].[Na+].O>CO>[C:1]([N:5]1[C:10](=[O:11])[C:9]([Cl:12])=[C:8]([S:14][CH2:15][C:16]2[CH:21]=[N:20][C:19]([O:22][CH2:23][C:24]([F:27])([F:25])[F:26])=[CH:18][CH:17]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 27822252-Tert-butyl-4,5-dichloro-2,3-dihydropyridazin-3-oneHCID 14671831HCID 14671831, compound

Product 1

HCID 14671832HCID 14671832, compoundYield 88.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 40 ml of methanol were dissolved 2.2 g of 2-t-butyl-4,5-dichloro-3(2H)-pyridazinone and 2.4 g of 5-mercaptomethyl(2,2,2-trifluoro-ethoxy)-pyridine, and thereto was added 1.2 g of sodium carbonate. The reaction mixture was stirred overnight at room temperature and then poured into water. Then, procedures similar to those in Preparation Example 24 were conducted to obtain 3.6 g of 2-t-butyl-4-chloro-5-[{6-(2,2,2-trifluoroethoxy)-3-pyridyl}-methylthio]-3(2H)-pyridazinone, m.p. 109.0°~110.0° C.

Workup

  1. customThen, procedures similar to those in Preparation Example 24

Sources & evidence

ORD record
ord-8fd7afa473f24817bcb0e937de184c53
Source dataset
uspto-grants-1989_06
Patent number
US04837217

Reaction notes

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