2,2-Dimethoxypropane → HCID 20038761, compound

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Reaction Steps

A mixture of ethyl 7-allylamino-1H-pyrazolo[4,3-b]-pyridine-6-carboxylate (3.69 g, 15 mmol), 2,2-dimethoxypropane (9.2 ml, 75 mmol) and 4-toluenesulphonic acid (142 mg, 0.75 mmol) in acetone (200 ml) was heated under reflux for 48 h. The solution was cooled and stirred with solid potassium carbonate, then filtered and evaporated in vacuo. Column chromatography of the residue on basic alumina (100 g), eluting with ethyl acetate, gave the title compound as a white solid (3.07 g, 64%), m.p. 102°-103° C. Found: C, 60.31; H, 6.78; N, 17.60; C16H22N4O3 requires C, 60.36; H, 6.97; N, 17.60%

Provenance & Evidence