Water → HCID 20038774, compound

Participants

Reaction Steps

A solution of ethyl 7-allylamino-2-(2-methoxy-2-propyl)-2H-pyrazolo[4,3-b]pyridine-6-carboxylate (2.38 g, 7.5 mmol) in dry THF (tetrahydrofuran) (25 ml) was added dropwise to an ice-cooled suspension of lithium aluminium hydride (285 mg, 7.5 mmol) in dry THF (15 ml). The mixture was stirred at room temperature, under nitrogen, for 24 h, then water (0.3 ml), 10% sodium hydroxide solution (0.3 ml) and water (0.85 ml) were added sequentially. The mixture was filtered through Kieselguhr, the solvent was evaporated in vacuo, and the residual solid was recrystallised from ethyl acetate to give the title compound as needles (1.87 g, 90%), m.p. 152°-154° C. Found: C, 60.58; H, 7.21; N, 20.26C14H20N4O2 requires C, 60.84; H, 7.29; N, 20.27%

Provenance & Evidence