反应详情

Ethyl 2-acetyl-3-(4-pyrazolylamino)acrylate (D13, 1.0 g, 4.5 mmol) was added to boiling Dowtherm A, and the solution was heated under reflux for 20 min. The mixture was allowed to cool and 60°-80° petroleum ether (100 ml) was added. The solid was filtered off and washed well with petroleum ether to give the title compound (590 mg, 74%), m.p.>320° C.

1. temperaturethe solution was heated
2. temperatureunder reflux for 20 min
3. additionwas added
4. filtrationThe solid was filtered off
5. washwashed well with petroleum ether