Water → HCID 20038781, compound

Participants

Reaction Steps

A solution of ethyl 7-allylamino-2-methyl-2H-pyrazolo-[4,3-b]pyridine-6-carboxylate (100 mg, 0.38 mmol) in dry THF (2 ml) was added dropwise to an ice-cooled suspension of lithium aluminium hydride (15 mg, 0.39 mmol) in THF (1 ml). The mixture was stirred at room temperature, under nitrogen, for 16 h, then water (0.03 ml), 10% sodium hydroxide solution (0.4 ml) and water (0.09 ml) were added sequentially. The solids were filtered off and washed with ethyl acetate. The solution was evaporated in vacuo to give a solid, which was recrystallised from ethyl acetate to give the title compound as needles (40 mg, 48%), m.p. 151°-159° C.

Provenance & Evidence