Isobutylamine → HCID 20038756, compound

Participants

Reaction Steps

9-Chloro-5,6,7,8-tetrahydro-1H-pyrazolo[4,3-b]quinoline (4.90 g, 0.024 mole) and isobutylamine (11.7 ml, 0.118 mole) were heated under reflux under nitrogen in dry xylene (50 ml) for 6 days. The solution was concentrated to dryness, the residue dissolved in water/methanol and the solution adjusted to pH 9-10 by addition of 10% sodium carbonate solution. The precipitate was filtered of, washed with water, dried and recrystallised from ethyl acetate to give the title compound as a beige solid (0.85 g, 15%), m.p. 124°-127° C. Found: C, 68.45; H, 8.55; N, 22.80%. C14H20N4 requires C, 68.80; H, 8.25; N, 22.95%.

Provenance & Evidence