2,6-Dimethylmorpholine → HCID 53873157, compound

Participants

Reaction Steps

3-(m-Phenoxyphenyl)-2-methyl-2-propenyl bromide (1.0 g) was added to 2,6-dimethylmorpholine (2.0 g) at 0° C. while stirring, followed by aging at the same temperature for 3 hours. Ice water (100 ml) and 15% aqueous sodium hydroxide solution (30 ml) were added to the resultant mixture to make basic, followed by extraction with ethyl acetate (50 ml×3). The extracts were combined together, washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography to give 4-[3-(m-phenoxyphenyl)-2-methyl-2-propenyl]-2,6-dimethylmorpholine (cis-isomer, 0.3 g).

Provenance & Evidence