2,6-Dimethylmorpholine → HCID 14553929, compound

Participants

Reaction Steps

2,6-Dimethylmorpholine (10.0 g) was heated to 100° C. with stirring, and 3-(m-methoxymethoxyphenyl)-2-methylpropyl-p-toluenesulfonate (5.0 g) was dropwise added thereto in 1 hour. The reaction mixture was aged at 100° C. for 2 hours with stirring, cooled to room temperature, and after addition of 15% aqueous sodium hydroxide (50 ml), extracted with diethyl ether (50 ml×3). The organic layer was combined, washed with a saturated aqueous sodium chloride, dried over magnesium sulfate and concentrated under reduced pressure to give 4-[3-(m-methoxymethoxyphenyl)-2-methylpropyl]-2,6-dimethylmorpholine (1.2 g).

Provenance & Evidence