反应详情

温度

0 °C

2.23 g of this acetamide was dissolved in a mixed solvent of 30 ml of methanol and 3 ml of water, and cooled in an ice bath. 0.48 g of 85% potassium hydroxide was added to this solution, and stirred at 0° C. for 1.5 hours. pH of the reaction solution was adjusted to 7 by adding 2N aqueous hydrochloric acid, and extraction was carried out by adding 100 ml of dichloromethane and 50 ml of water. The dichloromethane layer was washed twice with water, and dried over anhydrous magnesium sulfate. The solvent was evapoated in vacuo to obtain the captioned colorless oily N-[3-{3-(piperidinomethyl)phenoxy}propyl]-2-mercaptoacetamide. Yield: 1.86 g.

1. temperaturecooled in an ice bath
2. additionby adding
3. extraction2N aqueous hydrochloric acid, and extraction
4. additionby adding 100 ml of dichloromethane and 50 ml of water
5. washThe dichloromethane layer was washed twice with water
6. dry with materialdried over anhydrous magnesium sulfate