N-bromobutanimide → HCID 19867087, compound

Participants

Reaction Steps

To a stirred suspension of 8-methyl-6-(2,4-dimethylimidazol1-yl)-2-(1H)-quinolone (0.5 g) in chloroform (10 cm3) was added N-bromosuccinimide (NS) (0.374 g) at room temperature. After 5 minutes the reaction mixture was evaporated to dryness and the residue chromatographed on silica (Merck "MK 60.9385" [Trade Mark]) eluting with ethyl acetate:methanol, 10:1. Combination and evaporation of the appropriate fractions afforded a solid which on recrystallisation from ethyl acetate/methanol gave 8-methyl-6-(5-bromo-2,4-dimethylimidazol-1-yl)-2-(1m.p. 273°, (0.277 g).

Provenance & Evidence