HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → Diethyl tetrahydropyran-4,4-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | Bis(2-chloroethyl) ether | HCID 8115 | — |
| Reactant | Oxane-4-carboxylic acid | HCID 219302 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Product | Diethyl tetrahydropyran-4,4-dicarboxylate | HCID 239606 | — |
Reaction Steps
According to the statements in J. Chem. Soc., 2525-30 (1930) esters of tetrahydropyran-4-carboxylic acid can be prepared by treating 2,2'-dichlorodiethyl ether with the sodium salt of diethyl malonate to form diethyl tetrahydropyran-4,4-dicarboxylate, hydrolyzing to obtain tetrahydropyran-4,4-dicarboxylic acid, decarboxylating to tetrahydropyran-4-carboxylic acid, and finally esterifying.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04837346 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-a8c27a264e3d405fba7b285bb8635425 |
| Source note | uspto-grants-1989_06 |