Methanol → Methyl 4-nitro-L-phenylalaninate hydrochloride

Participants

Reaction Steps

Thionyl chloride (distilled, 0.69 ml, 9.5 mmol) was added dropwise to methanol (20 ml) at 31 10° C. p-Nitro-L-phenylalanine (1.00 g, 4.76 mmol) was added and the solution stirred 24 hours at room temperature. After evaporating to dryness, the residue was recrystallized from methanol/ether to give 1.00 g of a white solid melting at 218°-219° C. [α]25 =+11.5° (c=0.9, H2O).

Provenance & Evidence