2,6-Lutidine → HCID 131715955, compound

Participants

Reaction Steps

To a dichloromethane solution (1.0 ml) of Nα-t-butoxycarbonyl-Nε-benzyloxycarbonyllysine methyl ester (191.0 mg, 0.48 mmol) were added 2.6-lutidine (113 μl, 0.97 mmol) and t-butyldimethylsilyltrifluoromethane sulfonate (167 μl, 0.73 mmol). The mixture was stirred for 15 minutes in an argon atmosphere at room temperature. After addition of a saturated aqueous solution of ammonium chloride, the reaction mixture was extracted with ether and the ether layer was dried over anhydrous magnesium sulfate and filtered. After removal of the solvent in vacuo, Nα-butyldimethylsilyloxycarbonyl-Nε-benzyloxycarbonyllysine methyl ester was obtained (238 mg; yield, 100%).

Provenance & Evidence