Pyridine → HCID 20066897, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of indazole (L) (150 mg), pyridine (0.05 ml) and methylene chloride (2 ml), at -20° C., was added cyclopentyl chloroformate (0.07 ml). The reaction was warmed to 25° C. and stirred for 1 hour. The reaction mixture was added to ethyl acetate, and the ethyl acetate solution washed with saturated sodium carbonate, 1N HCl, and brine, and dried (MgSO4). Evaporation and trituration with diethyl ether gave methyl 4-[6-(cyclopentyloxycarbonyl)aminoindazol-1-ylmethyl]-3-methoxybenzoate (M) (148 mg, 73%) as a solid; mp 150.0°-151.0° C.

Provenance & Evidence