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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 190452Generated: October 30, 2026

1,2-Dichloroethane → (RS)-1-[2-(5,6-Difluoro-1H-benzoimidazol-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazol-4-yl]-methanone

https://huagongshe.com/reaction/190452

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-DichloroethaneHCID 11—
ReactantHydrochloric AcidHCID 313—
ReactantDimethylformamideHCID 6228—
Reactant1-HydroxybenzotriazoleHCID 75771—
ReactantHCID 17973671HCID 17973671—
Reactant5-(4-Fluoro-phenyl)-2-hydroxymethyl-thiazole-4-carboxylic acidHCID 23450138—
Product(RS)-1-[2-(5,6-Difluoro-1H-benzoimidazol-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazol-4-yl]-methanoneHCID 17973696—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
ORD IDord-445be072dca34a488b37799866c538ac
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (6/10)