Piperidin-2-ylmethanol → HCID 20037300, compound

HRID 1904526Notes

Reaction equation

HRID 1904526 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][NH:4]1.[Cl:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][C:13]([N:18]=[C:19]=[S:20])=[C:12]([F:21])[CH:11]=1>CCOCC>[Cl:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][C:13]([NH:18][C:19]([N:4]2[CH2:5][CH2:6][CH2:7][CH2:8][CH:3]2[CH2:2][OH:1])=[S:20])=[C:12]([F:21])[CH:11]=1

Participants

4

Reactant 2

HCID 94263Piperidin-2-ylmethanolHCID 11031300HCID 11031300, compound

Product 1

HCID 20037300HCID 20037300, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
30 °C

Procedure

11.5 g (0.10 mol) of 2-hydroxymethylpiperidine are dissolved in 100 ml of ether, and 21.8 g (0.10 mol) of 4-chloro-2-fluoro-5-methoxyphenyl isothiocyanate are added dropwise at RT. The mixture is stirred for 2 hours at 30° C., washed with twice 100 ml of water and dried over sodium sulfate, and the solvent is removed. 32.6 g (98% of theory) of 1-[N-(4-chloro-2-fluoro-5-methoxyphenyl)thiocarbamoyl]-2-hydroxymethylpiperidine are obtained in the form of a pale yellow viscous oil.

Workup

  1. washwashed with twice 100 ml of water
  2. dry with materialdried over sodium sulfate
  3. customthe solvent is removed

Sources & evidence

ORD record
ord-257b6cec90d84b01a64323d2befd5729
Source dataset
uspto-grants-1989_06
Patent number
US04838931

Reaction notes

Loading…