Toluene → HCID 14152793, compound

HRID 1904559Notes

Reaction equation

HRID 1904559 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[CH3:5][O:6][C:7]1([CH3:25])[CH2:12][CH2:11][C:10]2[CH:13]=[C:14]([O:17][C:18]3[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=3)[CH:15]=[CH:16][C:9]=2[O:8]1.C1(C)C=CC=CC=1>CCCCCC>[CH3:1][NH:2][C:3]([NH:22][C:21]1[CH:23]=[CH:24][C:18]([O:17][C:14]2[CH:15]=[CH:16][C:9]3[O:8][C:7]([O:6][CH3:5])([CH3:25])[CH2:12][CH2:11][C:10]=3[CH:13]=2)=[CH:19][CH:20]=1)=[O:4]

Participants

5

Reactant 3

HCID 1140TolueneHCID 12228Methyl IsocyanateHCID 14307273HCID 14307273, compound

Product 1

HCID 14152793HCID 14152793, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Methyl isocyanate (0.16 g) was added at room temperature to a solution composed of 0.4 g of 4-(2-methoxy-2-methyl-2,3-dihydro-6-benzopyranyloxy)aniline and 3.0 ml of toluene, and the mixture was stirred for 6 hours. Addition of n-hexane to the mixture yielded crystals which were collected by filtration to give the desired product as white crystals (yield not less than 97%).

Workup

  1. customyielded crystals which
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-4909d1b64ebf4ac8bf1ec18dc9be5231
Source dataset
uspto-grants-1989_06
Patent number
US04838924

Reaction notes

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