2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → HCID 86743130, compound

Participants

Reaction Steps

A solution of ethyl 2-(m-chlorophenylmethylen)-4-chloro-3-oxobutanoate (5 g) and ethyl-3-aminocrotonate (2.3 g) in EtOH (50 ml) is stirred at room temperature for four hours, then it is evaporated at reduced pressure, the residue dissolved in Et2O (70 ml) washed with water (3×20 ml), dried on Na2SO4 and purified by column-chromatography on silica gel (120 g; eluent hexane/AcOEt 60/40) to give 4.2 g of 2-amino-7-chloro-3,5-dicarboethoxy-6-oxo-4-(m-chlorophenyl)-2-heptene as an oil.

Provenance & Evidence