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HRID1904580

反应详情

EQUATION

反应方程式

HRID 1904580 的结构方程式

REACTANTS

反应物

2
结构：[I-].[K+]
HCID4875

Potassium iodide

IK

结构：CCOC(=O)C1=C(C)NC(CCl)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1
HCID3064723

Diethyl 2-(chloromethyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

C19H21ClN2O6

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C(C)NC(CI)=C(C(=O)OCC)C1c1cccc([N+](=O)[O-])c1
HCID20037475

未命名化合物

收率 36%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 2-chlorometyl-3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine (0.5 g) and potassium iodide (1 g) in acetone (5 ml) is stirred at room temperature for 24 hours, then it is filtered, concentrated under reduced pressure and the residue purified by column chromatography on silica gel (20 g, eluent: hexane/AcOEt 80/20) to give 0.22 g of 2-iodomethyl-3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine as an oil.

WORKUP

后处理

  1. filtrationit is filtered
  2. concentrationconcentrated under reduced pressure
  3. customthe residue purified by column chromatography on silica gel (20 g, eluent: hexane/AcOEt 80/20)