Dichloromethane → HCID 53932650, compound

HRID 1904586Notes

Reaction equation

HRID 1904586 reaction equation
[CH2:1]=[C:2]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]([NH:5][N:6]1[CH2:11][CH2:10][S:9][CH2:8][CH2:7]1)=[O:4].C(Cl)Cl.[C:22]([OH:25])(=[S:24])[CH3:23]>>[C:22]([S:24][CH2:1][CH:2]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:3]([NH:5][N:6]1[CH2:7][CH2:8][S:9][CH2:10][CH2:11]1)=[O:4])(=[O:25])[CH3:23]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 20037673HCID 20037673, compoundHCID 178418634HCID 178418634, compound

Product 1

HCID 53932650HCID 53932650, compound

Procedure

0.6 g of the product of Step A was stirred for 24 hours at ambient temperature in 10 ml of thioacetic acid and the excess of acid was eliminated under an inert atmosphere at 40°-45° C. The residue was taken up on 200 ml of methylene chloride, washed with a sodium bicarbonate solution, dried and the solvent was eliminated under reduced pressure. The residue was taken up in isopropyl ether to obtain 0.72 g of the expected product melting at 138° C.

Workup

  1. customwas eliminated under an inert atmosphere at 40°-45° C
  2. washwashed with a sodium bicarbonate solution
  3. customdried

Sources & evidence

ORD record
ord-7fe43d5f822b4aedadcfb10b5b8450d2
Source dataset
uspto-grants-1989_06
Patent number
US04839358

Reaction notes

Loading…