HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-8-(benzylthio)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid → HCID 14501368, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-8-(benzylthio)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid | HCID 14501371 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 14501368 | HCID 14501368 | — |
Reaction Steps
It is further contemplated that (S)-8-(benzylthio)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid can be treated with Raney nickel in ethanol to give (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid, the compound of Example 3(c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04839355 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-d49fcbabbfd8409585e47ee4f835ad0c |
| Source note | uspto-grants-1989_06 |