反应详情

温度

-60 °C

A 22 L flask was charged with 740 g of 4-bromo-2,6-lutidine and 10.0 L of diethyl ether and cooled to -60° C. in a Dry Ice/acetone bath under nitrogen. A solution of 4.0 moles of n-butyllithium was added dropwise over 1 hour maintaining a temperature below -58° C. to form an orange-yellow precipitate. After continued stirring in the cold for 15 minutes, 1280 g of tributyltin chloride was added over 2 hours at a temperature of -60° to -57° C. to form a solution. The reaction was stirred cold for 45 minutes before it was slowly (2 hours) warmed to 20° C. A portion of Super-Cel (100 g) was added and the reaction mixture was filtered to remove the precipitated lithium chloride. The cake was washed with diethyl ether (2×500 mL). After concentration to dryness a total of 1575 g (99.7% yield) of product was obtained which was used without further purification.

1. temperaturemaintaining a temperature below -58° C.
2. customto form an orange-yellow precipitate
3. customto form a solution
4. stirringThe reaction was stirred cold for 45 minutes before it
5. custom(2 hours)
6. temperaturewarmed to 20° C
7. additionA portion of Super-Cel (100 g) was added
8. filtrationthe reaction mixture was filtered
9. customto remove the precipitated lithium chloride
10. washThe cake was washed with diethyl ether (2×500 mL)