反应详情

(2)-(b) To a suspended solution of 2.0 g of 5-anilino-5-(4-chlorophenyl)pentanoic acid in 10 ml of toluene and 520 mg of pyridine was added 1.21 g of acetic anhydride at 25° C., and the solution was stirred at same temperature for 1.5 hours. Then, the reaction solution was treated in the same manner as in Example 1-(2)-(a) to give 1.51 g of 6-(4-chlorophenyl)-1-phenyl-2-piperidone.