Aniline → 1,5-Diphenylpyrrolidin-2-one

Participants

Reaction Conditions

Reaction Steps

To 20 g of 4-phenyl-γ-butyrolactone were added 28 g of aniline and 7.6 g of aniline hydrochloride, and the mixture was heated with stirring at 180° C. for 5 hours while evaporating the water formed. After cooling, 200 ml of benzene was added, and the mixture was washed with 10% hydrochloric acid and a saturated aqueous sodium chloride solution and dried. After removal of the solvent, the residue was recrystallized from ethyl acetate to give 24.9 g of 1,5-diphenyl-2-pyrrolidone.

Provenance & Evidence