Boron tribromide → HCID 14576902, compound

Participants

Reaction Steps

To a solution of 670 mg of 6-(3,4-dimethoxyphenyl)-1-(4-chlorophenyl)-2-piperidone in 17 ml of methylene chloride was added, under ice-cooling, 1.0 ml of boron tribromide, and the mixture was stirred under ice-cooling for 1 hour and at room temperature for 45 minutes. The mixture was treated with ice-water, extracted with chloroform. The extracts were washed with water, dried, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate to give 480 mg of 6-(3,4-dihydroxyphenyl)-1-(4-chlorophenyl)-2-piperidone as colorless prisms.

Provenance & Evidence