m-Chloroperbenzoic acid → HCID 14576906, compound

Participants

Reaction Steps

To a solution of 1.70 g of 1-(4-chlorophenyl)-6-(4-methylsulfinylphenyl)-2-piperidone in 50 ml of methylene chloride was added 1.02 g of m-chloroperbenzoic acid with stirring at 5° to 10° C. over 30 minutes. After stirring at 5° to 10° C. for 1 hour and at room temperature for 1 hour, the mixture was made alkaline with a saturated aqueous sodium hydrogen carbonate solution. The methylene chloride layer was washed with water, dried, and concentrated. The residue was recrystallized from nitroethane to give 1.54 g of 1-(4-chlorophenyl)-6-(4-methylsulfonylphenyl)-2-piperidone as colorless prisms.

Provenance & Evidence