Methanol → HCID 14576907, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2.5 g of 1-(4-chlorophenyl)-6-(4-methylsulfonylphenyl)-2-piperidone in 10 ml of methylene chloride, 15 ml of anhydrous trifluoroacetic acid was added, and the mixture was refluxed at 45° C. for 3 hours. After cooling, 100 ml of a mixture of methanol and triethylamine (1:1) was added, and the mixture was stirred at room temperature for 1 hour and then treated with a saturated aqueous ammonium chloride solution. The methylene chloride layer was washed with water, dried, and evaporated to give 2.2 g of 1-(4-chlorophenyl)-6-(4-mercaptophenyl)-2-piperidone as pale yellow oily product.

Provenance & Evidence