Trifluoroacetic acid → HCID 71311, compound

Participants

Reaction Steps

7-[2-Methoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-[2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid benzhydryl ester (0.11 g) was dissolved in anisole (0.33 mg), to which was added trifluoroacetic acid (1.1 ml) under ice-cooling. The solution so obtained was stirred for 1 hour under ice-cooling and the reaction solution was admixed with isopropyl ether (30 ml) to deposit a precipitate. The precipitate was recovered by filtration, washed with isopropyl ether and dried under reduced pressure. 7-[2-Methoxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-[2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid (syn-isomer) trifluoroacetate (0.067 g) was obtained.

Provenance & Evidence