Acetic Acid → HCID 20037817, compound

HRID 1904676Notes

Reaction equation

HRID 1904676 reaction equation
[C:1]([CH2:6][N:7]1[N:11]=[N:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH2:19][C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[N:21]=3)[CH:13]=2)=[N:8]1)([O:3]CC)=[O:2].C(O)(=[O:32])C>C(O)C.[OH-].[Na+].O>[C:1]([CH2:6][N:7]1[N:11]=[N:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]([C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[N:21]=3)=[O:32])[CH:13]=2)=[N:8]1)([OH:3])=[O:2]

Participants

6

Reactant 2

HCID 176Acetic AcidHCID 20037770HCID 20037770, compound

Product 1

HCID 20037817HCID 20037817, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 1.3 g of 2-carbethoxymethyl-5-[3-(2-quinolylmethyloxy)phenyl]tetrazole in 5 ml ethanol and 40 ml of 1N NaOH was stirred at 70° C. for 4 hours. It was cooled, diluted with water, acidified with acetic acid, filtered, washed with water, and then ethyl acetate to give 1.0 g product.

Workup

  1. temperatureIt was cooled
  2. filtrationfiltered
  3. washwashed with water

Sources & evidence

ORD record
ord-9419fccab8244462a0a8a8b98149465b
Source dataset
uspto-grants-1989_06
Patent number
US04839369

Reaction notes

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