Sodium Hydroxide → HCID 178419994, compound

Participants

Reaction Steps

A mixture of 8.6 g of 4(2-quinolylmethyloxy)phenylacetonitrile, 6.1 g of sodium azide and 5.0 g of ammonium chloride was heated with 70 ml of dry dimethylformamide at 140° C. for twenty hours. The reaction mixture was poured onto ice, basified with 1N sodium hydroxide and extracted 2 times with ethyl acetate. The aqueous fraction was extracted 2 times with ethyl acetate. Removal of solvent left 10.3 g of crude product. This was crystallized from methanol:ethyl acetate to yield 3.3 g of pure product of m.p. 173°-175° C.

Provenance & Evidence