Potassium Fluoride → HCID 14071292, compound

Participants

Reaction Conditions

Reaction Steps

In 300 ml of dimethylsulfoxide was dissolved 14.0 g of N-(2',6'-diisopropylphenyl)-3-nitrophthalimide, and 10.0 g of potassium fluoride was added to the solution. The mixture was heated on an oil bath at 100° C. for 3 hours. The liquid reaction mixture was concentrated under reduced pressure below 80° C., and the residue was extracted with ethyl acetate. The ethyl acetate solution was washed with water, dried and concentrated. Then, 20 ml of methanol was added to the residue, and the mixture was cooled and allowed to stand still. The compound 3 was precipitated in the form of colorless crystals. The amount obtained of the crude product was 10.1 g, yield: 77.6%. The crude crystals were recrystallized from methanol two times to obtain 4.5 g of pure crystals.

Provenance & Evidence