Ethyl isothiocyanatoformate → HCID 12803107, compound

HRID 1904772Notes

Reaction equation

HRID 1904772 reaction equation
[CH2:1]([O:3][C:4]([N:6]=[C:7]=[S:8])=[O:5])[CH3:2].[NH2:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][CH:14]=[C:13]2[CH2:19][C:20]#[N:21]>C(#N)C.O>[C:20]([CH2:19][C:13]1[C:12]2[C:16](=[CH:17][CH:18]=[C:10]([NH:9][C:7]([NH:6][C:4](=[O:5])[O:3][CH2:1][CH3:2])=[S:8])[CH:11]=2)[NH:15][CH:14]=1)#[N:21]

Participants

5

Reactant 2

HCID 85320Ethyl isothiocyanatoformateHCID 12803100HCID 12803100, compound

Product 1

HCID 12803107HCID 12803107, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

Ethoxycarbonyl isothiocyanate (1.2 ml) was added dropwise to a stirred solution of 5-amino-1H-indole-3-acetonitrile (1.7 g) in dry acetonitrile (50 ml). After 10 min. the resulting suspension was diluted with water (40 ml) and stirred for 20 min.

Sources & evidence

ORD record
ord-5a97d164391646e1b6fd0e6d7adf99e9
Source dataset
uspto-grants-1989_06
Patent number
US04839377

Reaction notes

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