HCID 14068930, compound → HCID 14068940, compound

HRID 1904783Notes

Reaction equation

HRID 1904783 reaction equation
[CH2:1]([N:5]1[C:10](=[O:11])[CH:9]2[C:7]([C:12]3[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=3)([CH2:8]2)[C:6]1=[O:21])[CH:2]([CH3:4])[CH3:3]>C(O)C.[Pd]>[NH2:18][C:15]1[CH:14]=[CH:13][C:12]([C:7]23[CH2:8][CH:9]2[C:10](=[O:11])[N:5]([CH2:1][CH:2]([CH3:3])[CH3:4])[C:6]3=[O:21])=[CH:17][CH:16]=1

Participants

4

Reactant 1

HCID 14068930HCID 14068930, compound

Product 1

HCID 14068940HCID 14068940, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Following the procedure of Example 3, a solution of 0.55 g of 3-isobutyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione in 25 ml of ethanol is hydrogenated in the presence of 0.1 g of 5% palladium on carbon and worked up, affording the title compound which melts at 115°-117° C. after recrystallisation from ether/petroleum ether.

Sources & evidence

ORD record
ord-c83b9887586a40e7bb37c6fbaf915aaa
Source dataset
uspto-grants-1989_06
Patent number
US04839379

Reaction notes

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